Dietary Effect of Silk Protein on Colon Cancer of Animal
2007
Yeo, J.H. (National Institute of Agricultural Science and Technology, RDA, Suwon, Republic of Korea), E-mail: [email protected] | Lee, K.G. (National Institute of Agricultural Science and Technology, RDA, Suwon, Republic of Korea) | Woo, S.O. (National Institute of Agricultural Science and Technology, RDA, Suwon, Republic of Korea) | Kweon, H.Y. (National Institute of Agricultural Science and Technology, RDA, Suwon, Republic of Korea) | Han, S.M. (National Institute of Agricultural Science and Technology, RDA, Suwon, Republic of Korea) | Park, K.H. (Kyung Hee University, Seoul, Republic of Korea) | Kim, S.S. (Chung-Ang University, Seoul, Republic of Korea)
This study was done for the dietary effect of silk protein, molecular controlled silk sericin and silk fibroin, on colon cancer of animal. The ICR mice were given weekly injections of 1,2-dimethylhydrazine (DMZ) for the initial 10 mg/kg with four weeks, and fed a diets supplemented with 3% (v/v) molecular controlled sericin and fibroin for 6 weeks, respectively. Then, the body weight, efficiency of dietary, typical histologic appearance of animal colon tissue and COX-2 effect were studied, too. Molecular controlled sericin protein are shown more higher dietary effect on animal colon cancer than fibroin supplemental case. The results suggest a potential usefulness of sericin as a chemopreventive for colon carcinogenesis and the development functional food.
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