Dietary nucleotides: potential contenders as feed additive for monogastrics? | Prehranski nukleotidi: potencialni kandidati kot aditivi za monogastride?
2009
Sauer, N., Hohenheim Univ. (Germany). Institute of Animal Nutrition | Bauer, E. | Mosentih, R.
Weaning is associated with morphological, histological and microbial dysfunctions in the gastrointestinal tract of young monogastrics. Since the ban of in feed antibiotics in 2006, nutritional strategies are being developed to aid young animals to overcome weaning-associated problems and withstand infectious diseases. Among others, dietary nucleotides are one group of bioactive agents which may have the potential to diminish challenges related to weaning. Nucleotides are low-molecular-weight intracellular compounds. They are involved in many biochemical processes, e.g. as monomeric units of nucleic acids, in transferring chemical energy, in biosynthetic pathways, as biological regulators and as coenzyme-components. Nucleotides are naturally present in all foods and feeds of animal and vegetable origin, but in lower concentrations than in mammalian milk. Several studies have been performed investigating possible effects of dietary nucleotides in monogastrics. The present review summarizes effects of dietary nucleotides on various aspects of body function and metabolism, including e.g. effects on the liver and intestine, but also on immune system, as well as on the intestinal microbiota. With respect to more practical aspects, effects on growth performance are also addressed.
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