Similaries and differences between haptoglobin in mammals and PIT 54 in poultry
2010
Georgieva, T., Thracian University, Stara Zagora (Bulgaria)
The acute phase response - APR is a natural systemic reaction raised to neutralize the effect of challenging agents - infections, traumas, neoplasms, immune disorders that impair the homeostasis. Acute phase proteins - APP are a component of APR. The purpose of the present review is to summarize the available information about haptoglobin - Нр in mammals and its analogue PIT 54 in Gallus gallus domesticus. Hp is a major APP in ruminants and a representative of moderate APP in men, carnivores, horses and rabbits. Chicken PIT 54 is a soluble mеmber of the so-called scavenger receptor cystein rich proteins family. Нр is an α2-glycoprotein that belongs to transport - metal-binding conjugated proteins. The primary function of Hp is to bind free haemoglobin and thus, to protect the orga¬nism from losing iron. The peroxidase activity of Hb is at the basis of assay methods for this protein. The review presents data about the development of knowledge about mammalian Hp and analysis of its biochemical properties. A special attention is paid on the information relation to biosynthesis and properties of mammalian Hp and the avian haemoglobin-binding protein called PIT 54. The investigation of the latter is essential for the timely detection of subclinical infections.
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