Changes in the content of neuropeptides in intestinal lymph nodes of pigs suffering from experimental Brachyspira hyodysenteriae infection
2009
Lakomy, M.,University of Warmia and Mazury, Olsztyn (Poland). Faculty of Veterinary Medicine | Winnicka, A.,Warsaw Agricultural Univ. (Poland). Faculty of Veterinary Medicine | Wasowicz, K.,University of Warmia and Mazury, Olsztyn (Poland). Faculty of Veterinary Medicine | Zmudzki, J.,National Veterinary Research Inst., Pulawy (Poland) | Kaleczyc, J.,University of Warmia and Mazury, Olsztyn (Poland). Faculty of Veterinary Medicine | Sienkiewicz, W.,University of Warmia and Mazury, Olsztyn (Poland). Faculty of Veterinary Medicine | Podlasz, P.,University of Warmia and Mazury, Olsztyn (Poland). Faculty of Veterinary Medicine
Several studies were performed in order to investigate the mutual interrelationship of the peripheral nervous system and particular types and subtypes of lymphocytes located in the intestinal lymph nodes of the pig. Using the ELISA method and the flow cytometry the tissue concentration of the vasoactive intestinal polypeptide (VIP), substance P (SP), GAL and SOM, as well as the number of lymphocytes containing antigens CD2, CD21, CD4, CD5, CD8 and TCRgamma/delta were determined. A significant increase in SP and GAL concentrations was shown in the lymph nodes of 4-months old experimental pigs. No significant differences in the concentrations of VIP and SOM were detected. As regards changes in the lymphocyte subpopulations of CD21+, CD4+/CD8+ and TCRgd+/CD8_ (regarded as a subpopulation of NK cells) lymphocytes, the mean frequency of CD21+ changed from 50.05% in control pigs to 25.82% in animals suffering from dysentery, the number of CD4+/CD8+ lymphocytes changed from 6.98% to 18.97%, and at the same period, the subpopulations of TCRgd+/CD8- lymphocytes changed from 17.76% to 0.38%.
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