Effect of nutritional status on the subsequent resistence of Haemonchus contortus to bencimidazoles in sheep | Efecto del nivel de nutrición sobre la resistencia de Haemonchus contortus frente a bencimidazoles en ovejas
2009
Calvete, C., Centro de Investigación y Tecnología Agroalimentaria de Aragón, Zaragoza (España) | Calavia, R., Centro de Investigación y Tecnología Agroalimentaria de Aragón, Zaragoza (España) | Ferrer, L.M., Universidad de Zaragoza (España). Facultad de Veterinaria | Ramos, J.J., Universidad de Zaragoza (España). Facultad de Veterinaria | Lacasta, D., Universidad de Zaragoza (España). Facultad de Veterinaria | Ruiz de Arcaute, M., Universidad de Zaragoza (España). Facultad de Veterinaria | Valderrábano, J., Centro de Investigación y Tecnología Agroalimentaria de Aragón, Zaragoza (España) | Uriarte, J., Centro de Investigación y Tecnología Agroalimentaria de Aragón, Zaragoza (España)
A study was conducted to examine the effect of host nutrition on resistance levels of H. contortus to bencimidazoles estimated by faecal egg count reduction test (FECRT) after administration of Albendazol (5mg/hg) and egg hatch test (EHA) carried out with a single discriminant dosis of thyabendazol (0,1 micro g/ml). Pregnant ewes were given access to lucerne pelleted diet etiher ad libitum or at approximately 0.70 of their maintenance requirements from the 35nd day of pregnancy in order to achieve a clearly differentiated level of body reserves by the 90th day of pregnancy, when all ewes in both groups received 5000 infective larvae of H. contortus. Then, all animals were put on the same plane of nutrition till the end of the study. Estimation of anthelmintic resistance was performed in day 56th after infection. The animal fat back showed a significant effect on the subsequent measured resistence levels. Mean percentage reduction (95% confidence interval) of faecal egg counts was higher in ad libitum group 90,27% (79,24 _ 94,60) than in restricted feed group 75,72% (66,77 _ 84,79) whereas, accordingly, mean percentage of hatched eggs both in control and in thyabendazol added wells was higher in this last group. Results herein suggest that host immune response modulated by nutritional status can highly influence anthelmintic resistance measured by FECRT and EHA.
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