Serum components inhibiting bacterial lipopoly. Saccharide (endotoxin) sensitization of erythrocytes
1973
Assoku, R.K.G., Department of Animal Science, University of Ghana, Legon
Examination of a variety of normal animal and human sera (horse, cow, sheep, pig, dog, rabbit, guinea-pig, mouse, chicken and human) showed that a high concentration of certain lipid-like, heat-stable,non-gammaglobulin, non-specific substance(s), which inhibit erythrocyte sensitization by bacterial lipopolysaccharide (LPS or endotoxin), were uniformly present. These inhibitors, determined to act by either neutralizing or altering the LPS in such a way as to prevent its subsequent adsorption by the erythrocytes, were also shown to be significantly decreased in concentration at the peak of the haemolytic episode during acute Salmonella gallinarum infection. The inhibition process was found to take place rapidly and the inhibitor-LPS bonding (combination) was also established as being very firm. There was also a direct relationship between the inhibitor and LPS concentration: the more concentrated the LPS, the more serum was required to produce complete inhibition of sensitization of erythrocytes. These, and the conditions necessary for in vivo sensitization during infection, were discussed in relation to the probable role of the inhibitors in the defence of the body against Gram-negative bacterial infection.
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