Percutaneous Bone Marrow Grafting in Radial Fracture in Rabbits
2003
Tavassoly, A., Pathology Dept., Faculty of Veterinary Medicine, Tehran University,Tehran, Iran | Raji, M., Resident of Orthopaedic Surgery, Faculty of Medicine, Tehran Medical SciencesUniversity, Emam Khomeini Hospital, Tehran, Iran
The osteogenicity and effect on early bone repair of bone marrow grafts were investigated. The purpose of this experimental study was to determine whether bone marrow grafted percutaneously leads to increased bone production or has any effect on the early healing of fractures. Thirty adolescent, male white rabbits were used. All of them had bilateral radial osteotomies. Rabbits were divided to equal five groups. The cross-sectional area of callus, breaking load, tensile strength and callus volume parameters at the fracture site were tested. At two weeks postgrafting callus volume were significantly higher (0.001P0.005) in grafted radii than in the contralateral saline control. By four weeks all parameters were significantly greater in the bone marrow grafted radii than in the control. Serial radiographs and histology confirm this advanced fracture healing in the grafted bones. There were no differences between the external callus of treated and control radii but the internal callus between the end of the cortical bone did show a difference between the two sides. Percutaneous bone marrow grafting is a simple semiinvasive technique that may have potential clinical application.
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