Field trial of the intranasal inoculation method of classical swine fever vaccine(LOM-850)
2009
Lee, O.S. (National Veterinary Research and Quarantine Service, Anyang, Republic of Korea), E-mail: [email protected] | Tark, D.S. (National Veterinary Research and Quarantine Service, Anyang, Republic of Korea) | Yang, D.K. (National Veterinary Research and Quarantine Service, Anyang, Republic of Korea) | An, S.H. (National Veterinary Research and Quarantine Service, Anyang, Republic of Korea) | Jun, M.H. (Chungnam National University, Daejeon, Republic of Korea)
In field experiments, the established intranasal inoculation system(1∨st; intranasal(IN) inoculation within 12 hours after birth and 2∨nd; intramuscular(IM) inoculation at 7~8 weeks old) was applied in 3 pig farms. Any adverse reactions were not observed when a total of 2,500 pigs were examined to evaluate the safety of IN inoculation system. The piglets born from the sows with antibody levels of 1:128 to 1:1,024 were vaccinated by the IN inoculation method by the same method as above and precolostrum inoculation method(1∨st; IM injection before colostrum-uptake and 2∨nd; IM inoculation at 7~8 weeks old). Similar levels of antibody were observed at 21~22 weeks old in both groups. In order to analyze priming effects of IN inoculation, the groups primed by IN vaccination(10∨6.0TCID∧50/mL) within 12 hours after birth and booster-vaccinated IM(10∨6.0TCID∧50/mL) at 7~8 weeks old, and the groups vaccinated IM(10∨3.0TCID∧50/mL)without priming, were compared in the conventional pig farms. At 11 weeks old, the primed groups showed higher level of immunity than the group without priming. Therefore, priming by the IN vaccination was presumed effective.
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