A study on the Establishment of Korean PTWI for Cadmium Based on The Epidemiological Data
2009
Choi, C.W., National Institute of Food and Drug Safety Evaluation, Seoul, Republic of Korea | Moon, J.H., National Institute of Food and Drug Safety Evaluation, Seoul, Republic of Korea | Park, H.S., National Institute of Food and Drug Safety Evaluation, Seoul, Republic of Korea | Ryeom, T.K., National Institute of Food and Drug Safety Evaluation, Seoul, Republic of Korea | Lee, K.H., National Institute of Food and Drug Safety Evaluation, Seoul, Republic of Korea | Lee, H.M., National Institute of Food and Drug Safety Evaluation, Seoul, Republic of Korea
There are differences of Cadmium (Cd) urinary concentration which is considered as indicator of renal tubular dysfunction in other countries, so we have reviewed domestic epidemiological data and suggested Korean health based guidance value (HBGV) for Cd to improve an efficiency of risk management. We decided to apply the WHO calculation model which considered the relationship between dietary intake and Cd concentration in urine sample. It is determined that Cd concentration 2.5 ug/g creatinine in urine as the prevalence of renal tubular dysfunction based on epidemiological data, because there is no renal tubular dysfunction and injury/lesion such as proteinuria at the concentration of 11.63 ug/g creatinine which is the highest Cd concentration in urine from the domestic epidemiological data. It is identified that the ratio between the Cd dietary consumption (8.3~10.4 ug/day) and Cd urinary concentration (0.38 ug/g creatinine) in Korean adult who predicting never been exposed to Cd are 21.8~27.3 and then it is applied to the corresponding model suggested by WHO. Also it is applied that 10% of bioavailability and 50% of excretion rate of absorbed to body (the ratio is 24) were assumed. The estimate of daily Cd consumption level which begins tubular dysfunction is 1 ug/kg bw/day, so we suggest the Korean provisional tolerable weekly intake (PTWI) as 7 ug/kg bw/week.
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