Toxic Effects of Thimerosal on Rat Midbrain Cells
2009
Choi, Y.W., National Institute of Toxicological Research, Seoul, Republic of Korea | Kwack, S.J., National Institute of Toxicological Research, Seoul, Republic of Korea
Thimerosal has been used as an additive to biologics and vaccines because it is very effective in killing bacteria used in several vaccines and in preventing bacterial contamination. However, the toxic mechanism of thimerosal has not been cleared. The present studies were performed to investigate its cytotoxicity and toxic mechanisms. Thimerosal induced cytotoxicity and inhibited the proliferation and differentiation of the midbrain cells. The reactive oxygen species (ROS) generation was increased by thimerosal treatments. However, antioxicants, such as vitamin E and propyl gallate, protected the oxidative damage on midbrain cells and was recovered midbrain cell proliferation and differentiation. These results suggest that antioxidants provide protection of midbrain cells against cytotoxicity induced by thimerosal by facilitating cellular functions that reduce oxidative stress.
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