Evaluation of stability and potency of live attenuated rinderpest vaccine of lapinized-avianized tissue culture strain origin for the establishment of expiration period
2009
Yeh, J.Y., National Veterinary Research and Quarantine Service, Anyang, Republic of Korea | Kim, H.J., National Veterinary Research and Quarantine Service, Anyang, Republic of Korea | Nah, J.J., National Veterinary Research and Quarantine Service, Anyang, Republic of Korea | Park, J.Y., National Veterinary Research and Quarantine Service, Anyang, Republic of Korea | Lee, J.H., National Veterinary Research and Quarantine Service, Anyang, Republic of Korea | Seo, H.J., National Veterinary Research and Quarantine Service, Anyang, Republic of Korea | Kweon, C.H., National Veterinary Research and Quarantine Service, Anyang, Republic of Korea | Cho, I.S., National Veterinary Research and Quarantine Service, Anyang, Republic of Korea | Moon, J.S., National Veterinary Research and Quarantine Service, Anyang, Republic of Korea
In this study, we evaluated the stability and potency of live attenuated rinderpest vaccines of lapinized-avianized tissue culture strain origin, which had been produced annually from 2005 to 2008. When immune responses to the vaccines were evaluated using two Holstein calves weighing 100~150 kg, neutralizinng antibody titer of 1 : 16 was induced at 21 days post vaccination. When calves were also inoculated with vaccines lots that had been stored for 39 months at 4℃, same level of antibody titer was observed. Using the virus titer test, we found that all batches of the vaccine that had been kept for 3, 10, 15, 22, 27, 34, 39, and 45 months showed no significant loss of titers, and fulfilled the requirement necessary (greater-than or equal to 3 logTCID∧50) to be used as the national rinderpest vaccine reserve in Korea. In this study, we demonstrated that stability and potency of the rinderpest vaccines were maintained over three years when kept at 4℃ storage. This indicates that it maybe feasible to extend the expiration period of this vaccine from one year to three years.
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