Determination of mammalian toxicity of Cedrus deodara root oil, against albino rats (Wistar strain)
2008
Perveen, R. (Baqai Medical Univ., Karachi (Pakistan). Baqai Inst. of Pharmaceutical Sciences) | Naqvi, S.N.H. (Baqai Medical Univ., Karachi (Pakistan). Baqai Inst. of Pharmaceutical Sciences) | Azmi, M.A. (Baqai Medical Univ., Karachi (Pakistan). Baqai Inst. of Pharmaceutical Sciences) | Tariq, R.M. (Karachi Univ. (Pakistan). M.A.H. Qadri Biological Research Centre) | Ahmed, M. (Aga Khan Medical Univ., Karachi (Pakistan)) | Mehmood, S.
Mostly Cedrus deodara root oil has been analyzed for sesquiterpenes and hydrocarbons. However, in the present case GC-Mass analysis and spectral studies were done on root oil. This oil is being used orally as anti-ulcer agent by Hakeems. However, scientifically it is necessary that the toxicity level be determined against mammals. During present investigations mammalian toxicity was determined, by oral administration, against albino rats (Wister strain). The LD50 by probit mortality graph was found to be 34.4 gm/kg. This is quite safe as compared to Neem oil LD50 (5gm/kg).
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