Alpha tocopherol may reduce endosulfan induced toxicity in mice
2010
Nawaz, S.K. (Punjab Univ., Lahore (Pakistan). Dept. of Microbiology and Molecular Genetics) | Batool, R. (Punjab Univ., Lahore (Pakistan). Dept. of Zoology) | Arshad, M. (National Univ. of Science and Technology, Rawalpindi (Pakistan)) | Arshad, N. (Punjab Univ., Lahore (Pakistan). Dept. of Zoology)
The objective of the study was to analyze the protective role of vitamin E as an antioxidant against endosulfan induced toxication. Three different experiments were executed involving low level exposure (intermittent inhalation of saturated vapors of 375 ppm for a total of 6 minutes in 3 hours), medium level exposure (inhalation of saturated vapors of 375 ppm for 10 minutes/week) and high level exposure (05mg/Kg body weight through intramuscular injection) of endosulfan with and without supplementation of vitamin E. In all experiments, endosulfan intoxication led to the significant depletion in total protein, albumin, gamma globulin and a-gamma globulin, with elevation in albumin/globulin ratio. Vitamin treatment in low level toxicity experimental led to the reversion of total serum protein and gamma globulin levels to normal level in 30 days of treatment and serum globulin and a-gamma globulin after 15 days. Similar trend was observed in medium level toxicity.
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