Inhibition of mitochondrial Na dependent Ca2+ efflux from rat brain stem by 17 beta-estradiol
2009
Petrovic, S. | Milosevic, M. | Stanojevic, I. | Velickovic, N. | Drakulic, D. | Horvat, A., Vinca Institute of Nuclear Sciences, Belgrade (Serbia). Laboratory of Molecular Biology and Endocrinology
The role of membrane-bound estradiol in modulation of mitochondrial Ca2+ flux in nerve endings isolated from rat brain stem was examined. Physiological concentrations of 17beta-estradiol bind specifically to isolated mitochondria. At concentrations ranging from 1x10-10 to 2x10-9 moles/l, estradiol significantly (by 23-28%) decreases mitochondrial Na-dependent calcium efflux. Decreased calcium efflux was associated with increased affinity of the Na+/Ca2+ exchanger for Na+ and decreased capacity of the exchanger to extrude Ca2+. Calcium ion efflux modulation and mitochondrial ion retention may be the way that 17beta-estradiol exerts its role in nerve cell homeostasis.
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