Acetylsalicylic acid concentration in synovial fluid and cartilage of inflamed joint in domestic pig after iontophoresis
2006
Djurdjevic, S., Military Medical Academy, Belgrade (Serbia). Institute for Aviation Medicine | Milenkovic, D. | Djurovic, A. | Dedic, G.
Fourteen male domestic pigs, average body mass of 24.5 kg and eight weeks old were used in this study. Four days before acetylsalicylic acid (ASA) administering, an iantrogenic inflammation of two contra lateral anterior and posterior extremity knee joints was provoked by injecting 0.2 ml 10% turpentine oil solution. Flexible proofed carbonic electrodes were fixed transversally on the prepared skin of joints. 5 ml 5% ASA solution (0.25 g ASA) diluted in aqua redestillate was applied on the cathode area. The biological dose of galvanic current was 110 mAmin (5,5 mA x 20 min). Punction of synovial fluid and biopsy of hyaline periepiphyseal cartilage was performed. We found fast, rhythmic and almost regular rise of ASA concentration in synovial fluid of inflamed joint, correlated to time intervals. The highest ASA concentration in synovial fluid was statistically significantly higher than in cartilage. ASA penetration into cartilage was considerably weaker. Nevertheless, ASA concentration in cartilage will increase in time because of its high concentration in synovial fluid.
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