Фармакологическая активность и токсикологическая безопасность лекарственного средства растительного происхождения ФитоМП для местного лечения хирургической инфекции
2010
Frolova, A.V., Vitebsk State Medical Univ. (Belarus) | Petrov, V.V., Vitebsk State Academy of Veterinary Medicine (Belarus) | Kosinets, A.N., Vitebsk State Medical Univ. (Belarus) | Zholnerovich, M.L., Vitebsk State Academy of Veterinary Medicine (Belarus) | Grushin, V.N., Vitebsk State Medical Univ. (Belarus)
In the conditions of the Republic of Belarus by an example model of a purulent wound at rats there was realized an experimental study of pharmacological activity of a medical remedy PhytoMP (containing active substances of Macleaya microcarpa (Maxim.) Fedde of Papaveraceae family; and Plantago major L. of Plantaginaceae family) in the form of powder. It was established, that the intensity wound-healthing effect depended on a ratio of the components plume poppy / greater plantain 1 + 1:1, 2:1, 1:2. Studying of the remedy safety showed that PhytoMP in the maximal dozes was not toxic for animals after a single unitary intragastric administration in dose of 50000 mg/kg to mice and in dose of 20833 mg/kg to rats. The mentioned above indexes surpassed the recommended for human dose after application tonsilles (1,428 mg/kg) in 35014 and 14589 times, and also the recommended for human doses for application at a wound with size of 2x2 square cm (11,424 mg/kg) - in 4377 and 1824 times, respectively.
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