DNA damage of blood lymphocytes and neutrophils in cattle with lymphosarcoma
2011
Mohamed, T.,Zagazig Univ. (Egypt). Faculty of Veterinary Medicine | Endoh, D.,Rakuno Gakuen Univ., Ebetsu (Japan). School of Veterinary Medicine | Oikawa, S.,Rakuno Gakuen Univ., Ebetsu (Japan). School of Veterinary Medicine
The objective of the present study was to analyze the apoptotic process in peripheral blood mononuclear cells (PBMC) and polymorphonuclear neutrophil leukocytes (PMN) in cows clinically affected with lymphosarcoma. Thirteen cows were studied. Of them, eight, that were referred because of inappetance, loss of body condition, diarrhoea, constipation, protrusion of third eyelid, and exophthalmia, were seropositive for bovine leukemia virus (BLV) based on a serum enzyme-linked immunosorbent assay. Other animals were apparently healthy and were used as controls. DNA damage of PBMC and PMN was assessed using the Comet assay. The results obtained showed a statistically significant difference in DNA damage between the PBMC and PMN isolated from cows infected with BLV and PBMC and PMN isolated from healthy cows.
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