Methylglyoxal destroys Agrobacterium tumefaciens crown gall tumours in Nicotiana tabacum without any adverse effect on the host plant
2011
Ray, A.,Indian Association for the Cultivation of Science, Kolkata (India). Dept. of Biological Chemistry | Roy, C.,Bose Inst., Kolkata (India). Dept. of Botany | Ray, S.,Regent Estate, Kolkata (India) | Mazumder, M.,Indian Association for the Cultivation of Science, Kolkata (India). Dept. of Biological Chemistry | Sengupta, D.N.,Bose Inst., Kolkata (India). Dept. of Botany | Ray, M.,Indian Association for the Cultivation of Science, Kolkata (India). Dept. of Biological Chemistry
Methylglyoxal (MG) is a highly reactive alpha-oxoaldehyde, demonstrating anticancer effect on plant neoplastic tumours. In in vivo studies it was observed that MG destroyed crown gall tumours in Nicotiana tabacum produced by Agrobacterium tumefaciens, without any adverse effect on the host. The efficacy of MG in comparison to other anticancer drugs viz. cisplatin and ellagic acid in the treatment of crown gall was investigated. A slight degeneration of galls was noted in plants treated with cisplatin and ellagic acid but the plants died subsequently. With MG however, crown galls were completely cured and the plants completed their usual life cycle by flowering and producing seeds. MG inhibited the respiration of crown gall calluses suggesting that energy depletion resulted in tumour destruction.
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