Blood parameters and immune response are modified by carnosic acid included in the diet of fattening lambs | El ácido carnósico incluido en la dieta de corderos de cebo modifica parámetros sanguíneos y de la respuesta inmune
2011
Morán, L., Consejo Superior de Investigaciones Científicas, León (España). Instituto de Ganadería de Montaña | Andrés, S., Consejo Superior de Investigaciones Científicas, León (España). Instituto de Ganadería de Montaña | Bodas, R., Consejo Superior de Investigaciones Científicas, León (España). Instituto de Ganadería de Montaña | Prieto, N., Consejo Superior de Investigaciones Científicas, León (España). Instituto de Ganadería de Montaña | Pérez, V., Consejo Superior de Investigaciones Científicas, León (España). Instituto de Ganadería de Montaña | Giráldez, F.J., Consejo Superior de Investigaciones Científicas, León (España). Instituto de Ganadería de Montaña
Thirty-two Merino lambs fed barley straw and a concentrate alone (CONTROL group) or enriched with carnosic acid (0.6 g/kg dry matter (DM), CARN006 group , 1.2 g/kg DM, CARN012 group) or vitamin E (0.6 g/kg DM, VITE006 group) were used to assess the effect of these antioxidant compounds on blood parameters and immune response. Lambs were blood sampled after 5 weeks of being fed the experimental diets. Haemoglobin and red blood cells counts revealed interferences between dietary iron and antioxidants (vitamin E and carnosic acid), although the mean values for all these parameters were physiological in all the groups. Lymphocytes counts were lower in VITE006 group, but there was a trend towards a higher gamma-interferon production in this group, thus indicating the existence of more activated cells. The groups being fed carnosic acid did not show significant differences in gamma-interferon production when compared to CONTROL lambs, but higher monocytes counts were detected in CARN012 animals. The results obtained in the present study seem to indicate that vitamin E and carnosic acid could show different mechanisms of action on immune response.
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