Urinary excretion of naproxen after oral administration in human male volunteers
2006
Ahmed, A.
Humans are exposed daily to wide variety of foreign compounds called xenobiotics-substances absorbed across the lungs or skin or more commonly ingested either unintentionally as compounds present in food and drink or deliberately as drugs for therapeutic or recreational purposes. Many xenobiotics provoke biological responses. Such biological responses often depend on the conversion of absorbed substances in to active metabolites. The dose and the frequency of administration require to achieve effective therapeutic blood tissues level vary in different patients because of individual differences in drug distribution and the rate of metabolism and elimination These differences are due, to genetic factors and no genetic variables such as age, sex, liver size, liver function, circulation rhythm, body temperature, and nutritional and environmental factors such as concomitant exposure to inducers or inhibitors of drug metabolism. It is likely that the genetic and environmental base
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