Potential antitumor activity of two Polygonum species
2011
Mazid, M. A., University of Dhaka, Dhaka (Bangladesh). Department of Pharmaceutical Chemistry | Nahar, L., University of Wolverhampton, Wolverhampton (United Kingdom). School of Applied Sciences, Department of Pharmacy, Department of Pharmacy | Datta, B. K., University of Dhaka, Dhaka (Bangladesh). Department of Pharmaceutical Chemistry | Bashar, S. M. A.K., North South University, Dhaka (Bangladesh). Department of Pharmacy | Sarker,S. D., University of Wolverhampton, Wolverhampton (United Kingdom). School of Applied Sciences, Department of Pharmacy, Department of Pharmacy
Two Bangladeshi Polygonum species, P. barbatum (L.) Hara var. barbata (common name bekhanjabaj) and P. stagninum Buch.-Ham. ex Meissn. (common name ratooti sag or bara bishkatali), are perennial herbs of the family Polygonaceae. The genus Polygonum L. is well-known for its use in oriental traditional medicine systems for the treatment of various ailments including fever, pain, inflammation, infections, cancer and tumors. The extracts of P. barbatum var. barbata and P. stagninum were assessed for potential antitumor properties using the potato disc assay. All extracts showed a considerable level of potential antitumor activity. The petroleum ether extract of P. barbatum var. barbata and the n-hexane and ethyl acetate extracts of P. stagninum, having IC50 values of 290, 200 and 180 microg/disc, respectively, were the most active among the extracts. The methanol extracts of both plants were the least active and had an IC50 value of greater than 400 microg/disc. Overall, the extracts of P. stagninum showed better antitumor activity potential than the extracts of P. barbatum var. barbata
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