Potassium channels opener pinacidil have multiple effects on KCl-elicited contractions of isolated non-pregnant rat uterus
2011
Novaković, R., Faculty of Medicine, Belgrade (Serbia) | Milovanović, S., Faculty of Medicine, Foča (Bosnia and Herzegovina) | Ćupić, V., Faculty of Veterinary Medicine, Belgrade (Serbia) | Gojković-Bukarica, Lj., Faculty of Medicine, Belgrade (Serbia)
The effects of K+ channel opener, pinacidil on contractions provoked by contraction-stimulating KCl were investigated on isolated uterus of non-pregnant rats in oestrus. Pinacidil produced a more potent inhibition of 20 mM KCl–elicited contractions (pD2 = 6.57 microM) than of 40 or 80mMKCl–elicited contractions (pD2=5.11 and 5.19 microM, respectively). Glibenclamide, a selective blocker of adenosine triphosphate (ATP)-sensitive K+ (KATP) channels, antagonized the pinacidil-induced inhibition of contractions elicited by 20 mM KCl in a competitive manner. However, the pinacidil-induced inhibition of contractions provoked by 40 and 80 mM KCl glibenclamide was unable to prevent them. Pinacidil ability to completely relax the non-pregnant uterus pre-contracted with K+ -rich solution suggests that K+ channel-independent mechanism(s) also plays a part in its relaxant effect.
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