Antimicrobial and antimutagenic activity of some medicinal plants
2011
Hassan, A.A.
The widespread use of medicinal plants for medical purposes has increased dramatically due to their great importance on the public health. In this study, three medicinal plants, Anasatatic hierochuntica, Peganum harmala L. and Rosmarinus officinalis L. were selected to evaluate their antimicrobial, mutagenic and antimutagenic activities. The antimicrobial activity has been evaluated against some gram negative (Pseudomonas aeruginosa, E.coli), gram positive (Staphylococcus aurues) bacteria and bacteriophage F116. The results of inhibition zone and survival percentages indicated that, these plant extracts have a strong antimicrobial activity against the tested microorganisms. The killing effect was reached up to 98.14% against bacteria and 92.7% against bacteriophage F116. Mutagenic activity was evaluated using prophage induction and transduction assays. Neither released phage from lysogenic nor transductants cells have been observed in some treatments. This indicated that plant extracts have no mutagenic activity. The three plant extracts used in this study showed antimutagenic activity against the powerful mutagen agent, EMS.
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