The anti-parasitic efficacy of ivermectin and pyrantel pamoate compound against canine Toxocara canis and Trichuris vulpis
2011
Youn, H.J., Seoul National University, Seoul, Republic of Korea | Ra, J.C., RNL-Bio, Seoul, Republic of Korea | Kim, B.K., RNL-Bio, Seoul, Republic of Korea | Bae, B.K., Seoul National University, Seoul, Republic of Korea | Lim, Y.S., Seoul National University, Seoul, Republic of Korea | Kim, K.H., Seoul National University, Seoul, Republic of Korea | Lee, K.E., Seoul National University, Seoul, Republic of Korea
Toxocara (T.) canis and Trichuris (T.) vulpis are very important canine parasitic nematodes. T. canis parasitize in small intestine and T. vulpis parasitize in large intestine. In order to control of these nematodes, ivermectin and pyrantel pamoate compound was applied to the dogs infected with these parasites naturally and artificially. This drug was composed of 68.0 ㎍ of ivermectin and 57.0 mg of pyrantel pamoate for small animal, 136.0 ㎍ of ivermectin and 114.0 mg of pyrantel pamoate for middle animal, and 272.0 ㎍ of ivermectin and 227.0 mg of pyrantel pamoate for large animal. Ivermectin in this drug is activity to nematodes and ectoparisites. Pyrantel pamoate in this drug is also activity to nematodes. In this experiment, this drug had a good efficacy against T. canis and T. vulpis in the infected dogs.
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