Evaluation of intraocular penetration of topically administered tissue plasminogen activator in dogs.

Gerding P.A. Jr.; Eurell T.E.

Evaluation of intraocular penetration of topically administered tissue plasminogen activator in dogs.

1993

Gerding P.A. Jr. | Eurell T.E.

Topically administered tissue plasminogen activator (tPA) was evaluated for its penetration into aqueous humor of clinically normal dogs. Two concentrations of tPA (5 mg/ml and 10 mg/ml) were evaluated in a single-dose study, and a concentration of 5 mg of tPA/ml was used for a multiple-dose study. The contralateral eye served as a nontreated control. Enzyme substrate analysis of aqueous humor was used to determine tPA activity. The activity of tPA in aqueous humor was significantly (P < 0.05) greater in treated eyes of all dogs, compared with that in control eyes. Significant differences in activity of tPA were not detected at different doses in treated eyes.

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