Effects of methylated derivates of histamine on the isolated guinea pig aorta.
1993
Djuric D.M. | Andjelkovic I.Z. | Rosic M.A.
The effects of histamine and various methylated derivatives of histamine on the vascular system was investigated using isolated guinea pig aorta. The results suggest that in this preparation histamine derivatives with methylation of the nitrogen atom as opposed to the terminal carbon atom at the end of the histamine side chain does not produce significant H3 receptor activation, further methylation of the histamine ring in the 1 - or 3 - positions leads to a marked reduction of the vasoactive effects of the molecules.
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