Effects of the trypanocidal agents berenil and pentamidine on growth, enzyme activities, and polyamine concentrations in the rice blast pathogen Pyricularia oryzae and on powdery mildew infection of barley seedlings.
1995
Walters D.R. | Cowley T. | McPherson A.
The effects of the trypanocidal agents Berenil and pentamidine on growth and polyamine biosynthesis in the rice blast fungus Pyricularia oryzae were examined. Fungal growth was substantially reduced by as little as 0.02 mM pentamidine and 0.01 mM Berenil. These compounds also controlled infection of barley seedlings by the powdery mildew fungus Erysiphe graminis f.sp. hordei. with 1 mM Berenil or pentamidine reducing infection by 80 and 85%, respectively. Although both compounds reduced in vitro activity of S-adenosylmethionine decarboxylase (AdoMetDC), the effects of pentamidine were more pronounced. Neither inhibitor had any effect on the in vitro activities of ornithine decarboxylase (ODC) and spermidine/spermine acetyltransferase (SSAT). In in vivo studies, neither Berenil nor pentamidine significantly altered the activities of AdoMetDC, ODC or SSAT. Curiously, however, exposure of P. oryzae to either compound resulted in greatly increased putrescine and cadaverine concentrations and a much reduced spermine concentration. The changes in polyamine concentrations may be due, in part, to increased activity of polyamine oxidase in fungal tissue following treatment with Berenil or pentamidine.
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