Genetic control of Marek's disease virus-induced transient paralysis: association with the major histocompatibility complex [in chickens]. [Conference paper].
1980
Schierman L.W. | Fletcher O.J.
A Marek's disease virus (MDV)-induced syndrome, previously designated transient (or temporary) paralysis, was found to be controlled by genes within, or closely linked to, the major histocompatibility complex (B complex) of the chicken. Symptoms of affected birds, which appeared 9 to 12 days after MDV inoculation, included temporary leg and neck paralysis and ataxia. Inoculation of chicks from two closely related inbred lines (G-B1 and G-B2) with highly virulent MDV caused transient paralysis in up to 89 per cent of G-B2 (B('1)/B('2)) birds. Resistance is a dominantly inherited trait since G-B1 (B('1)/B('1)) and F1 (B('1)/B('2)) birds did not develop the disorder. Histological lesions definitive for transient paralysis susceptibility were not detectable. Incidence of MDV-induced lymphomas, which develop later, does not appear to be significantly different between lines G-B1 and G-B2.
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