The effect of fluoride on the serum level of calcium in the rat (Rattus norvegicus)
2012
Fočak, M., University of Sarajevo, Sarajevo (Bosnia and Herzegovina). Faculty of Science, Department of Biology | Hasković, E., University of Sarajevo, Sarajevo (Bosnia and Herzegovina). Faculty of Science, Department of Biology | Suljević, D., University of Sarajevo, Sarajevo (Bosnia and Herzegovina). Faculty of Science, Department of Biology
The effect of fluoride on the calcium level in serum was analyzed in the laboratory rat Rattus norvegicus. The control group consisted of 10, and the experimental group of 15 animals. In the experimental group, fluoride at a concentration of 3 mg/100 g body weight of rats was intramuscularly injected into the musculus gluteus maximus. The concentration of calcium was measured by the CPC method. The average serum calcium concentration was 2.46 mmol/l, with female rats having higher values of serum calcium than male rats. Fluoride caused the reduction of calcium concentration in serum (p is less than 0.05); the reduction was significantly expressed in female rats (p is less than 0.000).
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