Dipeptide metabolites from the marine derived bacterium Streptomyces acrymicini
2004
Hernández Isara L. C. | Macedo Mario L. | Berlinck Roberto G. S. | Ferreira Antonio G. | Godinho Mirna J. L.
The chemical investigation of the crude extract obtained from the growth media of the marine-derived actinomycete Streptomyces acrimycini isolated from marine sediments led to the isolation of two new dipeptide derivatives: 8-amino-[ 1,4] diazonane-2,5-dione (1) and leucyl-4-hydroxyproline (3). The dipeptides were isolated from the growth media by a series of chromatographic steps, and identified by analysis of spectroscopic data. The macrocyclic carbon backbone of 8-amino-[ 1,4] diazonane-2,5-dione has been previously reported only once in marinobactins, siderophores isolated from the marine bacterium Marinobacter sp.
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