Effect of Emblica officinalis fruit in combating mercury-induced hepatic oxidative stress in rats
2011
Singh, K.P. | Ahmad, A.H. | Singh, V. | Pant, K. | Rahal, A.
The antioxidative effect of Emblica officinalis (amla) in mercury-induced oxidative stress in rats was evaluated in the present study. Mercury chloride (0.5 mg/kg, sc) increased the lipid peroxidation and decreased the level of GSH, SOD and catalase in liver which could be reversed by 100 mg/kg of ethanolic EO fruit extract out of 2 doses (50 and 100 mg/ kg) tested in the study. The present study concluded that Emblica officinalis has the antioxidative and hepatoprotective activity in mercury-induced hepatic damage, as it decreases the lipid peroxide, GPT and increases the natural antioxidants in liver in dose-dependant manner.
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