In vivo Acute Toxicity of Silicon Dioxide Nanoparticle to Mice after Intraperitonial Injection
2011
Cha, C.N., Gyeongsang National University, Jinju, Republic of Korea | Jung, W.C., Gyeongsang National University, Jinju, Republic of Korea | Lee, Y.E., Gyeongsang National University, Jinju, Republic of Korea | Yoo, C.Y., Gyeongnam Provincial Namhae College, Namhae, Republic of Korea | Kim, G.S., Gyeongsang National University, Jinju, Republic of Korea | Kim, E.K., Gyeongsang National University, Jinju, Republic of Korea | Kim, S., Gyeongsang National University, Jinju, Republic of Korea | Lee, H.J., Gyeongsang National University, Jinju, Republic of Korea
For the application of nano-sized material in various fields, the evaluation of nano-sized material toxicity is important. In the present study, various concentrations of 200 nm-sized silicon dioxide nanoparticle suspension were intraperitonially injected into mice to identify the toxicity of silicon dioxide nanoparticle in vivo. In the hematological analysis of group Ⅱ treated with silicon dioxide nanoparticle 100 mg/kg body weight, lymphocytes and monocytes were significantly different compared to the control group. In group Ⅲ treated with silicon dioxide nanoparticle 200 mg/kg body weight, lymphocytes, monocytes and hemoglobin were significantly different compared to the control group. In blood biochemical analysis of group Ⅲ, the concentration of AST, ALT, BUN, and creatinine were significantly different compared to the control group. Histopathologic examination of the kidney indicated a mild injury only in mice received 200 mg/kg silicon dioxide nanoparticle. According to the results of the present study, the significant differences in the hematological and blood biochemical analyses and abnormal histopathological findings in the mouse kidney may have been related to exposure to silicon dioxide nanoparticle.
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