Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
2012
Lee, S.C., Dartmouth College, Hanover, Hew Hempshire, USA | Kim, Y.S., Pohang University of Science and Technology, Pohang, Republic of Korea | Jeon, U.S., Korea University Guro Hospital, Seoul, Republic of Korea | Kim, Y.K., Pohang University of Science and Technology, Pohang, Republic of Korea | Schjoerring, Jan K., University of Copenhagen, Denmark | An, G.H., Kyung Hee University, Yongin, Republic of Korea
Because micronutrients in human diets ultimately come from plant sources, malnutrition of essential minerals is a significant public health concern. By increasing the expression of nicotianamine synthase (NAS), we fortified the level of bioavailable iron in rice seeds. Activation of iron deficiency-inducible OsNAS2 resulted in a rise in Fe content (3.0-fold) in mature seeds. Its ectopic expression also increased that content. Enhanced expression led to higher tolerance of Fe deficiency and better growth under elevated pH. Mice fed with OsNAS2-D1 seeds recovered more rapidly from anemia, indicating that bioavailable Fe contents were improved by this increase in OsNAS2 expression.
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