Inhibitory Effect of Cirsium japonicum Root or Flower Extract on Hepatic Stellate Cells Activation
2012
Kim, S.J., Jeonju Biomaterials Institute, Jeonju, Republic of Korea | Kim, S.Y., Jeonju Biomaterials Institute, Jeonju, Republic of Korea | Kim, J.A., Jeonju Biomaterials Institute, Jeonju, Republic of Korea | Park, I.S., Jeonju Biomaterials Institute, Jeonju, Republic of Korea | Yu, K.Y., Jeonju Biomaterials Institute, Jeonju, Republic of Korea | Chung, C.H., Jeonju Biomaterials Institute, Jeonju, Republic of Korea | Shim, J.S., Imsil Herbal Medicine Association, Imsil, Republic of Korea | Jang, S.I., Jeonju University, Jeonju, Republic of Korea | Jeong, S.I., Jeonju Biomaterials Institute, Jeonju, Republic of Korea
This study was designed to elucidate the effects of Cirsium japonicum (CJ) extracts on hepatic stellate cells (HSCs, LX-2 cells) proliferation, which is induced by platelet-derived growth factor (PDGF) or transforming growth factor-β (TGF-β). The content of total phenol, flavonoid, and silymarin derivatives was more higher in CJ-flower than in CJ-root. Consistent with these results, the LX-2 cells growth inhibition was more effective in CJ-flower extract than in CJ-root extract, the complete growth inhibition concentration was 1 ㎍/mL and 50 ㎍/mL, respectively. These results suggest that extracts from CJ-flower can be potentially used as therapeutic substances for the regulatioin of HSCs activation.
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