Effects of Haberlea rhodopensis extract on antioxidation and lipid peroxidation in rabbits after exposure to 60 Co-Г-rays
2013
Popov, B. (Trakia University, Stara Zagora (Bulgaria). Department of Molecular Biology, Immunology and Medical Genetics) | Georgieva, S. (Trakia University, Stara Zagora (Bulgaria). Department of Genetics, Animal Breeding and Reproduction) | Oblakova, M. (Agricultural Institute, Stara Zagora (Bulgaria)) | Bonev, G. (Trakia University, Stara Zagora (Bulgaria). Department of Genetics, Animal Breeding and Reproduction)
Haberlea rhodopensis extract (HRE) possesses strong antioxidant activity. Te aim of the present study was to evaluate the protective ability of HRE against oxidative damage induced by a non-lethal dose of 60 Co-γ-rays. Experimental animals (New Zealand rabbits) were exposed to 2.0 Gy γ-rays before and aſter HRE administration. Lipid peroxidation (MDA) and activities of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) were analyzed. Results show that administration of HRE before and aſter irradiation decreased the MDA level and increased SOD and CAT activ- ity, thus providing protection against the radiation-induced decrease in antioxidative ability and increase in lipid peroxida- tion. Tis finding supports the idea that HRE is a potent free radical scavenger and antioxidant.
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