Determination of the plasma adprin concentrations and studies on its pharmacokinetics in chickens after oral administration | 阿德呋啉血药浓度的测定及其在鸡体内药代动力学研究
2013
Wu Lijun, Anhui Agricultural University, Hefei(China),College of Animal Science and Technology | Zeng Minghua, Anhui Agricultural University, Hefei(China),College of Animal Science and Technology | Yan Ran, Anhui Agricultural University, Hefei(China),College of Animal Science and Technology
chinois. 采用高效液相紫外检测法,测定了健康鸡灌服80 mg・kg-1阿德呋啉后血浆中药物浓度,药物浓度-时间数据用3P97药代动力学程序软件处理。血药浓度-时间数据符合一级吸收二室开放模型,其主要药代动力学参数分别为:血浆消除半衰期(T1/2β)(2.414±0.252)h,达峰时间(Tpeak)(1.429±0.053)h,达峰浓度(Cmax)(499.941±21.295)ng・mL-1,药时曲线下面积(AUC)(2 624.528±124.690)ng・h・mL-1。阿德呋啉在试验鸡体内的相对生物利用度为61.94%。结果表明:阿德呋啉在健康鸡体内的药代动力学特征表现为吸收迅速,相对生物利用度较高,消除缓慢,组织穿透性差,不易在机体中残留。
Afficher plus [+] Moins [-]anglais. This paper deals with the plasma adprin concentrations in chicken fed with 80 mg・kg-1 adprin by using high performance liquid chromatography.Plasma adprin pharmacokinetic variables are calculated by using a two-compartment model with 1st order absorption in chicken with 3P97 pharmacokinetics program.The main pharmacokinetics parameters are as follows:elimination half-lives of plasma adprin is (2.414±0.252)h;peaking time after dosing the drug to chickens is (1.429±0.053)h;the maximal plasma concentration is (499.941±21.295)ng・mL-1;the area under the curve of drug is(2 624.528±124.690)ng・h・mL-1 respectively in chicken.The relative bioavailability of adprin in chicken is 61.94%.The results suggested that the pharmacokinetic stigmata of adprin in healthy chicken are quick absorption,higher relative bioavailability,slow-elimination,bad-penetration and lower-residue in tissue.
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