Characterization of a CENP-B homolog in the holocentric Lepidoptera Spodoptera frugiperda
2011
D'Alençon , Emmanuelle (INRA , Montpellier (France). UMR 1333 Diversité, Génomes et Interactions Microorganismes-Insectes) | Nègre , Nicolas (Centre National de la Recherche Scientifique, Montpellier(France). UPR1142 Institute of Human Genetics) | Stanojcic , Slavica (INRA , Montpellier (France). UMR 1333 Diversité, Génomes et Interactions Microorganismes-Insectes) | Alassoeur , Benjamin (INRA , Montpellier (France). UMR 1333 Diversité, Génomes et Interactions Microorganismes-Insectes) | Gimenez , Sylvie (INRA , Montpellier (France). UMR 1333 Diversité, Génomes et Interactions Microorganismes-Insectes) | Leger , Alexandre (INRA , Montpellier (France). UMR 1333 Diversité, Génomes et Interactions Microorganismes-Insectes) | Abd-Alla , Adly (National Research Center, Giza(Egypte). Department of Pests and Plant Protection) | Juliant , Sylvie (Centre National de la Recherche Scientifique, Saint Christol les Alès(France). UPS 3044) | Fournier , Philippe (INRA , Montpellier (France). UMR 1333 Diversité, Génomes et Interactions Microorganismes-Insectes)
The discovery of an homolog of the human centromeric protein B, CENP-B, in an EST database of the holocentric insect species Spodoptera frugiperda prompted us to further characterize that gene because i) CENP-B has not been described in invertebrates yet ii) it should be a milestone in the molecular characterization of the holocentric centromere of Lepidoptera. Like its human counterpart, the Sj CENP-B protein is related to the transposase of the pogo transposable element (TE) of D. melanogaster. In this paper, we show evidences that the lepidopteran cenpB gene has evolved from domestication of a transposase. Furthermore, the Sj CENP-B nuclear location and its ability to bind to a retrotransposon derived sequence in vivo argue in favor of a functional homology to CENP-B proteins
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