Antibacterial activity and protective effect against gastric cancer by Anthriscus sylvestris fractions
2013
Cho, E.J., Pusan National University, Busan, Republic of Korea | Choi, J.M., Pusan National University, Busan, Republic of Korea | Kim, H.M., Chung-Ang University, Anseong , Republic of Korea | Choi, K., Korea National Arboretum, Pocheon, Republic of Korea | Ku, J.J., Korea National Arboretum, Pocheon, Republic of Korea | Park, K.W., Korea National Arboretum, Pocheon, Republic of Korea | Kim, J.K., Chung-Ang University, Anseong , Republic of Korea | Lee, S.H., Chung-Ang University, Anseong , Republic of Korea
The aim of this research was to investigate the industrial application of Anthriscus sylvestris. Antibacterial activities of the n-hexane, methylene chloride (MC), ethyl acetate, and butanol fractions of A. sylvestris were tested against Escherichia coli, Staphylococcus aureus, and Helicobacter pylori. The n-hexane and MC fractions showed a stronger antibacterial activity against S. aureus than other fractions, with an inhibition zone greater than 11 mm in disc assays. At 100 μg·mL -1 , all fractions extracted from A. sylvestris scavenged more than 85% of 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl radicals (·OH); however, the n-hexane and MC fractions showed the strongest scavenging activity of DPPH and ·OH. In addition, we found that treatment with the n-hexane and MC fractions inhibited the growth of H. pylori and gastric adenocarcinoma cells. Further testing of falcarindiol and deoxypodophyllotoxin from the MC fraction of A. sylvestris revealed the antibacterial effects against E. coli, S. aureus, and H. pylori, suggesting their potential use as antibacterial agents.
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