Effect of Mixture of Lactobacillus plantarum CECT 7527, 7528, and 7529 on Obesity and Lipid Metabolism in Rats Fed a High-fat Diet
2014
Kim, D.H., Hallym University, Chuncheon, Republic of Kroea | Choi, M.R., Hallym University, Chuncheon, Republic of Kroea | Hong, J.E., Hallym University, Chuncheon, Republic of Kroea | Lee, J.Y., Hallym University, Chuncheon, Republic of Kroea | Lee, S.I., Hanall BioPharma Co. Ltd., Seoul, Republic of Korea | Jung, S.H., Hanall BioPharma Co. Ltd., Seoul, Republic of Korea | Kim, E.J., Hallym University, Chuncheon, Republic of Kroea
In the present study, we examined the effects of a mixture of three strains, Lactobacillus plantarum CECT 7527, 7528, and 7529 (L. plantarum mixture), on body weight and lipid metabolism in Sprague-Dawley rats fed a high-fat diet. Rats were fed a high-fat diet and subjected to oral gavage with vehicle or the L. plantarum mixture (0.6¡¿10¡�9, 1.2¡¿109, 2.4¡¿10¡�9 colony-forming units (CFU)/day/rat, respectively) for 8 weeks. In rats fed a high-fat diet, oral administration of 2.4¡¿10¡�9 CFU/day of the L. plantarum mixture significantly reduced body weight gain as well as weights of liver and epididymal fat. Leptin levels in sera were significantly reduced by oral administration of 2.4¡¿10¡�9 CFU/day of the L. plantarum mixture. The L. plantarum mixture (1.2¡¿10¡�9 or 2.4¡¿10¡�9 CFU/day) also reduced the concentrations of total cholesterol and LDL-cholesterol in sera when it administered orally. Further, the L. plantarum mixture significantly reduced the atherogenic index and cardiac risk factor. In addition, oral administration of 2.4¡¿10¡�9 CFU/day of the L. plantarum mixture markedly reduced levels of total lipids, triglycerides, and total cholesterol in the liver. The results of this study indicate that the L. plantarum mixture may exhibit anti-obesity and cholesterol-lowering effects, which suggest that the L. plantarum mixture has the potential to be a probiotic in the management of obesity and hypercholesterolemia.
Afficher plus [+] Moins [-]Mots clés AGROVOC
Informations bibliographiques
Cette notice bibliographique a été fournie par Korea Agricultural Science Digital Library
Découvrez la collection de ce fournisseur de données dans AGRIS