Analysis of Pine Nut Oil Composition and Its Effects on Obesity
2014
Kim, K.K., Kangwon National University, Chuncheon, Republic of Korea | Kang, Y.H., Kangwon National University, Chuncheon, Republic of Korea | Kim, D.J., Kangwon National University, Chuncheon, Republic of Korea | Kim, T.W., Kangwon National University, Chuncheon, Republic of Korea | Choe, M., Kangwon National University, Chuncheon, Republic of Korea
Pine nut oil (PNO) is well known to impart beneficial effects in overweight individuals, but the mechanisms underlying PNO-mediated weight loss remain unclear. To investigate how PNO promotes weight loss, its composition was determined by gas chromatography coupled with mass spectrometry (GC-MS). In addition, the effects of PNO on cytotoxicity, lipid accumulation, expression of lipid metabolism-related biomarkers, and leptin secretion were assessed in 3T3-L1 cells. GC-MS analyses revealed that PNO contains several components, including linoleic acid, oleic acid, palmitic acid, and stearic acid. Moreover, PNO did not have a cytotoxic effect on 3T3-L1 cells. However, it inhibited the expression of peroxisome proliferator-activated receptor (PPAR) and adipocyte protein 2 (aP2). Finally, PNO significantly increased leptin secretion in a dose-dependent manner. Taken together, these results support the notion that PNO is useful for weight management in overweight individuals.
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