Molecular evaluation and pathogenicity index of avian influenza (H9N2) circulated in Shiraz.
2008
Mehrabanpour, Mohammad Javad | Shoushtari, Abdolhamid | Rahimian, Abdollah | Shirazy Njat, Ali | Hossaini, Seyed Mohammad
Influenza virus is one of the most important respiratory pathogen worldwide. H9N2 subtype of avian influenza viruses is widespread among domestic poultry and reported in the industrial population's poultry of Iran from 1998. In this study sequences of the hemagglutinin (HA) gene of 11 H9N2 subtypes of influenza viruses isolated from chicken in Iran during (1998-2010) were genetically analyzed. PCR products of 11 isolates were sequenced and then were aligned with the reported sequences in Gen bank. Three out of isolates had Leucine (L) at position 226 instead of glutamine (Q) which prevails in the sequences found in human H3 strain. Phylogenetic analysis showed that all our isolates belonged to the G1-like sublineage of Eurasia lineage. Amino acid sequence analysis of the HA gene showed that the Iranian isolates are very closely related (93/8-100%) and shared a homology (79/9-83) with H9N2 isolates from A/turkey/Wisconsin/66.The available evidence indicated that genes of H9 influenza virus circulating in Iran and it seems that the potential of Iranian avian influenza virus (H9N2) to infect human should be considered. Key words: avian influenza virus, H9N2, hemagglutinin gene, phylogenetic analysis.
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