Cell type-specific gene expression profiling in brain tissue: comparison between TRAP, LCM and RNA-seq
2015
Kim, T.H., Seoul National University, Seoul, Republic of Korea | Lim, C.S., Seoul National University, Seoul, Republic of Korea | Kaang, B.K., Seoul National University, Seoul, Republic of Korea
The brain is an organ that consists of various cell types. As our knowledge of the structure and function of the brain progresses, cell type-specific research is gaining importance. Together with advances in sequencing technology and bioinformatics, cell type-specific transcriptome studies are providing important insights into brain cell function. In this review, we discuss 3 different cell type-specific transcriptome analyses i.e., Laser Capture Microdissection (LCM), Translating Ribosome Affinity Purification (TRAP)/RiboTag, and single cell RNA-Seq, that are widely used in the field of neuroscience.
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