Effects of different fractionated radiation on pancreas in rats
2014
Xinjia He | Yuanyuan Zhao | Lihua Wang | Qingjun Shang | Yongheng An
Damages to the pancreas of rats after different fractionated irradiation were investigated. Adult Wistar rats were randomized into conventional fractionated, single high-dose, middle-dose fractionated radiation, and control groups. Changes in weight blood glucose concentration, and amylase level measured. Morphological changes were observed prior to and control groups. Changes in weight, blood glucose concentration, and amylase level were measured. Morphological changes were observed prior to post-irradiation. Blood glucose concentration decreased in the experimental groups after radiotherapy, especially in the single high-dose radiation and control groups, but the difference between conventional and middle-dose fractionated radiation groups was not significant. By contrast, the amylase level in the single high-dose radiation groups evidently increased after radiotherapy, but the difference between conventional and middle dose fractionated radiation groups was not significant. Under a light microscope, more severe pancreatic damages were observed in the single high dose-radiation group than in the conventional and middle-dose fractionated radiation groups. When proper fractional dose and intervals were chosen, the radiation damage after middle-dose fractionated radiotherapy was not more serious than that after conventional fractionated radiation, which provided scientific evidence for the development of hypofractionated radiotherapy for pancreas.
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