Comparative efficacy of various indigenous and allopathic drugs against ovine fasciolosis
2015
Masood-ul-Haq, K. (University of Veterinary and Animal Sciences, Lahore (Pakistan). Dept. of Parasitology) | Maqbool, A. (University of Veterinary and Animal Sciences, Lahore (Pakistan). Dept. of Parasitology) | Khan, U.J. (Government Post Graduate Coll. for Women, Lahore (Pakistan). Dept. of Zoology) | Kakar, A. (Lasbela Univ. of Agriculture, Water and Marine Sciences, Balochistan (Pakistan)) | Khan, M.S. (University of Veterinary and Animal Sciences, Lahore (Pakistan). Dept. of Clinical Medicine and Surgery) | Lateef, M.
A total of 110 animals were used in 11 controlled experiments to compare efficacy of plants, Saussurea lappa, Fumaria parviflora, Caesalpinia crista and an allopathic drug triclabendazole. Efficacy of drugs was measured by determining the difference of eggs per gram of faeces (EPG) pre and post-treatment. Saussurea lappa, after a single dose of 60, 70 and 80 mg/kg body weight, reduced EPG by 47.36, 48.57 and 55.55 percent, respectively. After the second dose the respective reduction in EPG was 81.57, 85.71 and 94.44 percent. Fumaria parviflora at a rate of 60, 70 and 80 mg/kg body weight was 41.66, 45.71 and 63.88 percent, respectively, whereas efficacy at two dose levels with the same dose rate was 83.33, 91.42 and 97.22 percent respectively. Caesalpinia crista at 60, 70 and 80 mg/kg body weight was 38.23, 45.71 and 51.42 percent dose levels. Allopathic drug i.e. Triclabendazole at 10mg/kg body was 88.89 percent effective on 18th day and 100% effective on 28 `h day. The efficacy order was triclabendazole, Fumaria parviflora (80 mg/kg), Saussurea lappa and Caesalpinia crista. No toxic effects were seen in any of these indigenous plant origin drugs.
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