Comparative in vivo biodistributions of nanoparticles and polymers of 177lutetium-labeled hyaluronic acids in mice during 28 days
2017
Lin, C., Jilin Agricultural University, Changchun, Republic of Korea | Jeong, J.Y., Chungbuk National University, Cheongju, Republic of Korea | Yon, J.M., Centers for Disease Control and Prevention, Cheongju, Republic of Korea | Park, S.G., Chungbuk National University, Cheongju, Republic of Korea | Gwon, L.W., Chungbuk National University, Cheongju, Republic of Korea | Lee, J.G., Chungbuk National University, Cheongju, Republic of Korea | Baek, I.J., Asan Medical Center and University of Ulsan, Seoul, Republic of Korea | Nahm, S.S., Konkuk University, Seoul, Republic of Korea | Lee, B.J., Chungbuk National University, Cheongju, Republic of Korea | Yun, Y.W., Chungbuk National University, Cheongju, Republic of Korea | Nam, S.Y., Chungbuk National University, Cheongju, Republic of Korea
Hyaluronic acid (HA) has been investigated for biomedical and pharmaceutical applications. This study was conducted to determine the distributions of HA nanoparticles (NPs; size 350-400 nm) and larger HA polymers in mice at intervals after application. 177Lutetium (Lu)-labeled HA-NPs or HA polymers were intravenously injected (5 mg/ kg) into male ICR mice, and radioactivity levels in blood and target organs were measured from 0.25 h to 28 days post-injection. In blood, the radioactivities of HA-NPs and HA polymer peaked at 0.5 h after injection but were remarkably decreased at 2 h; subsequently, they maintained a constant level until 6 days post-injection. HA-NPs and HA polymers were observed in the liver, spleen, lung, kidney, and heart (in ascending order) but were seldom observed in other organs. After 3 days, both the HA-NP and HA polymer levels showed similar steady decreases in lung, kidney, and heart. However, in liver and spleen, the HA-NP levels tended to decrease gradually after 1 day and both were very low after 14 days, whereas the HA polymer level accumulated for 28 days. The results indicate that HA-NPs, with their faster clearance pattern, may act as a better drug delivery system than HA polymers, especially in the liver and spleen.
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