The Pharmacognosical Study on the Citrus Fruit Peels cultivated in Jeju Island by Chemotaxonomy
2018
Kim, C.M., Kangwon National University, Chunchun, Republic of Korea | Baek, W.S., Korea Pharmaceutical Test and Research Institute, Seoul, Republic of Korea | Kwon, Y.S., Kangwon National University, Chunchun, Republic of Korea | Ko, K.S., Jeju Province Development Co., Jeju, Republic of Korea | Huh, I.O., Jeju National University, Jeju, Republic of Korea
Phytolaccae Radix has long been used as a traditional indigenous medicine to cure edema and rheumatism. However, there is insufficient background information on toxicological evaluation of Phytolaccae Radix extract to support the safe use. Therefore, we conducted a series of standardized, OECD and KFDA guidelines compliant in vivo study, to find a dose levels for the 13 weeks toxicity study. The extract of Phytolaccae Radix was administered orally to F344 rats at dose levels of 0, 500, 1000 and 2000 mg/kg/day for 2 weeks. Each group was composed to five male and five female rats. In the result, there were no test article-related adverse changes in clinical signs, body weight, food consumption, ophthalmology, hematology, clinical chemistry, gross finding at necropsy and organ weight examination. Therefore, we recommend that 2000 mg/kg/day is a highest treatment group in 13-week exposure study.
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