Effect of Abelmoschus esculentus extract on anti-melanogenesis and skin barrier function
2018
Kim, H.S., Jungwon University, Goesan, Republic of Korea
We investigated the application of functional materials by examining a variety of physiological activities of Abelmoschus esculentus extract. A. esculentus extract had a low cytotoxicity against murine melanoma B16F10 cells. At concentrations showing little or no cytotoxicity, A. esculentus extract showed high a DPPH radical scavenging activity (ID50, 5.24 μg/mL), inhibited tyrosinase activity (ID50, 102.12 μg/mL), and decreased melanin content (ID50, 17.85 μg/mL). The treatment of B16F10 cells with A. esculentus extract suppressed the protein expression of tyrosinase in a dosedependent manner. These findings suggest that A. esculentus extract inhibits melanin synthesis in murine melanoma B16F10 cells by suppressing intracellular tyrosinase expression, as well as directly inhibits tyrosinase activity simultaneously. Additionally, A. esculentus extract promotes the expression of involucrin, which is related to skin barrier protection. These results indicate that A. esculentus extract is an appropriate material for improving skin barrier function.
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