THE EFFECTS OF PLATELET RICH FIBRIN AND FIBRIN ADHESIVE ON WOUND HEALING: IMMUNOHISTOCHEMICAL RESULTS
2020
Durmuş, Ali Said | Çeribaşı, Ali Osman | İşgör, Eda
This study was conducted to determine the effects of platelet rich fibrin (PRF) and fibrin adhesive (FA) on wound healing. Fourteen New Zealand rabbits were divided into 2 groups for 7 and 14 day postoperative follow-ups. It was created four full-thickness wounds which 5 mm in diameter on the dorsal back skin of all rabbits. Saline solution were instilled to the control group, autogenous PRF, FA and PRF plus FA were used in other wounds, respectively (n = 14). Measurements of wound were performed every day. On days 7th and 14th after the operation, seven rabbits were euthanized and skin specimens were obtained for histological examinations. As a result of the measurements of the wound areas, it was determined that the healing of the experimental groups was better than the control group. Histological evaluations showed that the granulation tissue and collagen accumulation were in the best PRF group on the seventh day and inflammatory cell infiltration was observed in at least PRF group. In conclusion, it was concluded that PRF and FA accelerate wound healing, the best wound healing is observed in PRF plus FA group and PRF and FA can be used confidently in open wound treatment.
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