Experimental Models of Cryptococcosis
2012
Sabiiti, Wilber(School of Biosciences, University of Birmingham) | May, Robin C.(School of Biosciences, University of Birmingham) | Pursall, E. Rhiannon(School of Biosciences, University of Birmingham)
Cryptococcosis is a life-threatening fungal disease that infects around one million people each year. Establishment and progression of disease involves a complex interplay between the fungus and a diverse range of host cell types. Over recent years, numerous cellular, tissue, and animal models have been exploited to probe this host-pathogen interaction. Here we review the range of experimental models that are available for cryptococcosis research and compare the relative advantages and limitations of the different systems.
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