Enlargement of a Modular System—Synthesis and Characterization of an s-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load
Martin Kellert | Peter Lönnecke | Bernd Riedl | Johannes Koebberling | Evamarie Hey-Hawkins
The amount of boron accumulated in tumor tissue plays an important role regarding the success of the boron neutron capture therapy (BNCT). In this article, we report a modular system, combining readily available starting materials, like glycine, 1,3,5-triazine and the well-known 9-mercapto-1,7-dicarba-closo-dodecaborane(12), as well as &alpha:-d-galactopyranose for increased hydrophilicity, with a novel boron-rich tris-meta-carboranyl thiol.
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